The Ultimate Guide to Stereochemistry of Organic Compounds by Ernest L. Eliel
Stereochemistry of Organic Compounds Eliel Pdf Free
If you are interested in learning more about the three-dimensional aspects of organic molecules, you might want to read the book Stereochemistry of Organic Compounds by Ernest L. Eliel. This book is considered to be one of the most comprehensive and authoritative works on stereochemistry, covering both basic principles and practical aspects. In this article, we will explain what stereochemistry is and why it is important, who Ernest L. Eliel is and what are his contributions to stereochemistry, and how to download Stereochemistry of Organic Compounds Eliel Pdf Free online.
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What is stereochemistry and why is it important?
Stereochemistry is the branch of chemistry that deals with the spatial arrangement of atoms and groups in molecules. It studies how different configurations and conformations affect the physical, chemical, and biological properties of organic compounds. Stereochemistry is also known as 3D chemistry or molecular geometry.
Definition and examples of stereochemistry
The term stereochemistry was coined by Victor Meyer in 1894, from the Greek words stereos (solid) and chemia (chemistry). Stereochemistry can be divided into two main categories: static stereochemistry and dynamic stereochemistry.
Static stereochemistry focuses on the structure and classification of stereoisomers, which are molecules that have the same molecular formula but differ in their spatial arrangement. There are two types of stereoisomers: configurational isomers and conformational isomers.
Configurational isomers have different configurations, which means they cannot be interconverted without breaking or forming bonds. For example, enantiomers are configurational isomers that are mirror images of each other but are not superimposable. They have opposite optical activities, which means they rotate plane-polarized light in opposite directions. Another example of configurational isomers are diastereomers, which are not mirror images of each other and have different physical and chemical properties.
Conformational isomers have different conformations, which means they can be interconverted by rotation around single bonds. For example, ethane can exist in two conformations: staggered and eclipsed. The staggered conformation is more stable than the eclipsed conformation because it has less steric strain.
Dynamic stereochemistry studies the stereochemical changes that occur during chemical reactions or physical processes. It involves concepts such as stereoselectivity, stereospecificity, chirality transfer, inversion, retention, racemization, epimerization, etc.
Stereoselectivity refers to the preference for the formation of one stereoisomer over another in a reaction. For example, a stereoselective reaction can produce a mixture of enantiomers or diastereomers with different ratios.
Stereospecificity refers to the requirement for a specific configuration or conformation of the reactants or the products in a reaction. For example, a stereospecific reaction can produce only one stereoisomer or a pair of enantiomers.
Chirality transfer refers to the preservation or creation of chirality in a reaction. For example, a chiral reactant can transfer its chirality to a chiral product, or a prochiral reactant can become chiral after a reaction.
Inversion refers to the reversal of configuration or conformation in a reaction. For example, an SN2 reaction involves an inversion of configuration at the carbon atom that undergoes nucleophilic substitution.
Retention refers to the preservation of configuration or conformation in a reaction. For example, an SN1 reaction involves a retention of configuration at the carbon atom that undergoes nucleophilic substitution.
Racemization refers to the conversion of an optically active compound into a racemic mixture, which is a 50:50 mixture of enantiomers that has no optical activity. For example, an acid-catalyzed hydrolysis of an ester can cause racemization of the chiral alcohol product.
Epimerization refers to the interconversion of epimers, which are diastereomers that differ in configuration at only one stereogenic center. For example, an acid-catalyzed dehydration of an aldose can cause epimerization of the carbonyl group.
Applications and benefits of stereochemistry in organic chemistry
Stereochemistry is important in organic chemistry because it affects the structure, function, and reactivity of organic molecules. Some of the applications and benefits of stereochemistry are:
Stereochemistry helps to explain and predict the properties and behavior of organic compounds. For example, stereochemistry can help to determine the melting point, boiling point, solubility, polarity, acidity, basicity, stability, reactivity, and biological activity of organic compounds.
Stereochemistry helps to design and synthesize new organic compounds with desired properties and functions. For example, stereochemistry can help to create new drugs, pesticides, polymers, catalysts, sensors, materials, etc. with specific stereochemical features that enhance their performance and efficiency.
Stereochemistry helps to understand and control the mechanisms and outcomes of organic reactions. For example, stereochemistry can help to select the appropriate reagents, conditions, and catalysts for a reaction, as well as to analyze and optimize the yield and selectivity of a reaction.
Stereochemistry helps to elucidate and model the structure and function of biomolecules. For example, stereochemistry can help to determine the conformation and configuration of proteins, carbohydrates, lipids, nucleic acids, etc., as well as their interactions with other molecules and their roles in biological processes.
Who is Ernest L. Eliel and what are his contributions to stereochemistry?
Ernest L. Eliel was a renowned organic chemist and a pioneer in the field of stereochemistry. He was born in Germany in 1921 and immigrated to the United States in 1939. He received his Ph.D. from the University of Illinois in 1944 and became a professor at Notre Dame University in 1948. He moved to the University of North Carolina at Chapel Hill in 1972 and retired in 1991. He died in 2008 at the age of 86.
Biography and achievements of Ernest L. Eliel
Ernest L. Eliel was a prolific researcher, author, teacher, and leader in organic chemistry. Some of his achievements are:
He published over 400 scientific papers and 10 books on various topics in organic chemistry, especially stereochemistry. His books include Stereochemistry of Carbon Compounds (1962), Conformational Analysis (1965), Stereochemistry of Organic Compounds (1994), Elements of Stereochemistry (1996), The Stereochemistry Workbook (2000), etc.
He received numerous awards and honors for his contributions to chemistry, such as the Priestley Medal (1996), the National Medal of Science (1998), the Welch Award in Chemistry (2001), the Roger Adams Award (2004), etc. He was also elected to the National Academy of Sciences (1975) and the American Academy of Arts and Sciences (1980).
He served as the president of the American Chemical Society (1987), the International Union of Pure and Applied Chemistry (1990-1991), and the American Academy for Advancement of Science (1994). He also held various editorial positions for journals such 71b2f0854b